The first warm day of the year: the meadows bloom, pollens fly and rising complaints of many people. Diagnosis: hay fever. According to professionals: approximately 20 percent of the population suffers from the seasonal allergic rhinitis designated disease. It belongs to the atopic diseases and is associated with an increased production of IgE – antibodies, which are caused by the inflammation in the nasal mucosa. Consequences are in addition to the irritable cough, the itch and the secretion, clogging of the nose, medically described as obstruction. For the disease are not only genetic factors – the environmental factors also playing an important role. Thus, especially the industrialized nations, while the countries of the Third World hardly suffer from allergies. Reason is the high hygiene standard and the gains in quality of life in comparison to developing countries. The allergic rhinitis occurs when children makes an initial contact with potential allergens (substances that cause allergies can be), there is not yet described to the inflammatory reactions. Rather, this system of phagocytosis of the human body and the immune system are recognized and currently presented. The phagocytosis system is recently represented by macrophages, scavenger cells also, which there are unknown substances from the human body to eliminate. The immune systems antibodies are then able to defend our body against the unknown substance to form and for a repeated contact to protect the human world. A chronic course of the disease carries the risk of complications and long-term consequences: in addition to changes in the nasal mucosa can also be a disturbance of smell. Therefore, an urgent need for consistent treatment, therefore domestic funds are inappropriate. In addition to the H1-antihistamines and glucocorticoids, it has been a few years since hyposensitization is possible to perform. The concerned substrate allergen is injected with increasing doses. If the maximum dose is reached, followed by another three years in which immunotherapy is continued. Despite all the achievements, there is still much need of therapy.